| Costa Mesa to Saddlebrooke (Arizona) | 414.45 mi (666.99 km) |
| Costa Mesa to Safety Harbor (Florida) | 2,115.06 mi (3,403.86 km) |
| Costa Mesa to Saginaw (Michigan) | 1,939.11 mi (3,120.70 km) |
| Costa Mesa to Saginaw (Texas) | 1,186.42 mi (1,909.37 km) |
| Costa Mesa to Sahuarita (Arizona) | 420.85 mi (677.29 km) |
| Costa Mesa to Saks (Alabama) | 1,835.56 mi (2,954.05 km) |
| Costa Mesa to Salem (Massachusetts) | 2,593.79 mi (4,174.30 km) |
| Costa Mesa to Salem (Ohio) | 2,081.37 mi (3,349.64 km) |
| Costa Mesa to Salem (Oregon) | 823.92 mi (1,325.97 km) |
| Costa Mesa to Salem (Virginia) | 2,130.54 mi (3,428.78 km) |
| Costa Mesa to Salem Lakes (Wisconsin) | 1,720.48 mi (2,768.85 km) |
| Costa Mesa to Salida (California) | 331.06 mi (532.80 km) |
| Costa Mesa to Salina (Kansas) | 1,182.85 mi (1,903.62 km) |
| Costa Mesa to Salinas (California) | 296.06 mi (476.46 km) |
| Costa Mesa to Salisbury (Maryland) | 2,366.83 mi (3,809.05 km) |
