| Costa Mesa to Orangevale (California) | 392.86 mi (632.24 km) |
| Costa Mesa to Orchards (Washington) | 865.79 mi (1,393.35 km) |
| Costa Mesa to Orcutt (California) | 165.59 mi (266.48 km) |
| Costa Mesa to Oregon (Ohio) | 1,950.58 mi (3,139.16 km) |
| Costa Mesa to Oregon (Wisconsin) | 1,663.57 mi (2,677.26 km) |
| Costa Mesa to Oregon City (Oregon) | 843.96 mi (1,358.22 km) |
| Costa Mesa to Orem (Utah) | 571.99 mi (920.52 km) |
| Costa Mesa to Orinda (California) | 376.67 mi (606.19 km) |
| Costa Mesa to Orland Park (Illinois) | 1,723.11 mi (2,773.08 km) |
| Costa Mesa to Orlando (Florida) | 2,182.60 mi (3,512.56 km) |
| Costa Mesa to Ormond Beach (Florida) | 2,178.47 mi (3,505.91 km) |
| Costa Mesa to Oro Valley (Arizona) | 410.79 mi (661.11 km) |
| Costa Mesa to Oroville (California) | 450.94 mi (725.71 km) |
| Costa Mesa to Oshkosh (Wisconsin) | 1,721.92 mi (2,771.17 km) |
| Costa Mesa to Oskaloosa (Iowa) | 1,475.93 mi (2,375.28 km) |
