| Costa Mesa to Enumclaw (Washington) | 959.08 mi (1,543.49 km) |
| Costa Mesa to Ephrata (Pennsylvania) | 2,326.69 mi (3,744.44 km) |
| Costa Mesa to Erie (Colorado) | 835.66 mi (1,344.87 km) |
| Costa Mesa to Erie (Pennsylvania) | 2,125.23 mi (3,420.23 km) |
| Costa Mesa to Erlanger (Kentucky) | 1,880.33 mi (3,026.10 km) |
| Costa Mesa to Escanaba (Michigan) | 1,823.12 mi (2,934.03 km) |
| Costa Mesa to Escondido (California) | 60.87 mi (97.96 km) |
| Costa Mesa to Española (New Mexico) | 690.40 mi (1,111.08 km) |
| Costa Mesa to Essex (Maryland) | 2,315.81 mi (3,726.93 km) |
| Costa Mesa to Essex Junction (Vermont) | 2,482.21 mi (3,994.73 km) |
| Costa Mesa to Estelle (Louisiana) | 1,650.02 mi (2,655.45 km) |
| Costa Mesa to Estero (Florida) | 2,205.49 mi (3,549.40 km) |
| Costa Mesa to Euclid (Ohio) | 2,048.81 mi (3,297.24 km) |
| Costa Mesa to Eufaula (Alabama) | 1,898.98 mi (3,056.11 km) |
| Costa Mesa to Eugene (Oregon) | 770.10 mi (1,239.35 km) |
