| Costa Mesa to Emeryville (California) | 378.56 mi (609.23 km) |
| Costa Mesa to Emmaus (Pennsylvania) | 2,361.66 mi (3,800.72 km) |
| Costa Mesa to Emporia (Kansas) | 1,253.61 mi (2,017.48 km) |
| Costa Mesa to Encinitas (California) | 56.91 mi (91.58 km) |
| Costa Mesa to Endicott (New York) | 2,330.58 mi (3,750.70 km) |
| Costa Mesa to Endwell (New York) | 2,332.74 mi (3,754.18 km) |
| Costa Mesa to Englewood (Colorado) | 825.53 mi (1,328.56 km) |
| Costa Mesa to Englewood (Florida) | 2,159.70 mi (3,475.71 km) |
| Costa Mesa to Englewood (New Jersey) | 2,440.36 mi (3,927.38 km) |
| Costa Mesa to Englewood (Ohio) | 1,896.89 mi (3,052.75 km) |
| Costa Mesa to Enid (Oklahoma) | 1,147.45 mi (1,846.64 km) |
| Costa Mesa to Ennis (Texas) | 1,234.39 mi (1,986.55 km) |
| Costa Mesa to Ensley (Florida) | 1,799.94 mi (2,896.72 km) |
| Costa Mesa to Enterprise (Alabama) | 1,868.23 mi (3,006.62 km) |
| Costa Mesa to Enterprise (Nevada) | 222.22 mi (357.63 km) |
