| Costa Mesa to Desert Hot Springs (California) | 81.17 mi (130.62 km) |
| Costa Mesa to DeSoto (Texas) | 1,218.07 mi (1,960.30 km) |
| Costa Mesa to Destin (Florida) | 1,848.48 mi (2,974.84 km) |
| Costa Mesa to Destrehan (Louisiana) | 1,632.47 mi (2,627.20 km) |
| Costa Mesa to Detroit (Michigan) | 1,972.36 mi (3,174.20 km) |
| Costa Mesa to Diamond Bar (California) | 23.64 mi (38.05 km) |
| Costa Mesa to Diamond Springs (California) | 383.58 mi (617.31 km) |
| Costa Mesa to Dickinson (North Dakota) | 1,208.21 mi (1,944.43 km) |
| Costa Mesa to Dickinson (Texas) | 1,373.59 mi (2,210.58 km) |
| Costa Mesa to Dickson (Tennessee) | 1,732.54 mi (2,788.25 km) |
| Costa Mesa to Difficult Run (Virginia) | 2,269.26 mi (3,652.02 km) |
| Costa Mesa to Dinuba (California) | 215.87 mi (347.42 km) |
| Costa Mesa to Discovery Bay (California) | 358.36 mi (576.72 km) |
| Costa Mesa to Dix Hills (New York) | 2,473.87 mi (3,981.31 km) |
| Costa Mesa to Dixon (California) | 395.91 mi (637.15 km) |
