| Costa Mesa to Delhi (California) | 305.78 mi (492.10 km) |
| Costa Mesa to Delray Beach (Florida) | 2,302.70 mi (3,705.83 km) |
| Costa Mesa to Deltona (Florida) | 2,180.34 mi (3,508.92 km) |
| Costa Mesa to Deming (New Mexico) | 596.70 mi (960.30 km) |
| Costa Mesa to Denison (Texas) | 1,223.83 mi (1,969.57 km) |
| Costa Mesa to Dent (Ohio) | 1,876.61 mi (3,020.12 km) |
| Costa Mesa to Denton (Texas) | 1,195.97 mi (1,924.72 km) |
| Costa Mesa to Dentsville (South Carolina) | 2,108.69 mi (3,393.61 km) |
| Costa Mesa to Denver (Colorado) | 834.68 mi (1,343.29 km) |
| Costa Mesa to Depew (New York) | 2,198.14 mi (3,537.57 km) |
| Costa Mesa to Derby (Connecticut) | 2,485.28 mi (3,999.68 km) |
| Costa Mesa to Derby (Kansas) | 1,188.49 mi (1,912.69 km) |
| Costa Mesa to Des Moines (Iowa) | 1,431.64 mi (2,304.00 km) |
| Costa Mesa to Des Moines (Washington) | 975.63 mi (1,570.13 km) |
| Costa Mesa to Des Plaines (Illinois) | 1,725.84 mi (2,777.47 km) |
