| Columbus to Superior (Colorado) | 1,171.24 mi (1,884.94 km) |
| Columbus to Superior (Wisconsin) | 650.14 mi (1,046.30 km) |
| Columbus to Surprise (Arizona) | 1,678.23 mi (2,700.86 km) |
| Columbus to Susanville (California) | 1,970.63 mi (3,171.43 km) |
| Columbus to Sussex (Wisconsin) | 347.20 mi (558.76 km) |
| Columbus to Suwanee (Georgia) | 414.42 mi (666.94 km) |
| Columbus to Swansea (Illinois) | 387.25 mi (623.22 km) |
| Columbus to Sweetwater (Florida) | 993.13 mi (1,598.29 km) |
| Columbus to Sweetwater (Texas) | 1,098.52 mi (1,767.90 km) |
| Columbus to Sycamore (Illinois) | 327.84 mi (527.61 km) |
| Columbus to Sylacauga (Alabama) | 504.17 mi (811.38 km) |
| Columbus to Sylvania (Ohio) | 124.96 mi (201.11 km) |
| Columbus to Syosset (New York) | 502.02 mi (807.92 km) |
| Columbus to Syracuse (New York) | 411.91 mi (662.91 km) |
| Columbus to Syracuse (Utah) | 1,522.04 mi (2,449.49 km) |
