| Columbus to Storm Lake (Iowa) | 659.04 mi (1,060.63 km) |
| Columbus to Storrs (Connecticut) | 574.15 mi (924.00 km) |
| Columbus to Stoughton (Wisconsin) | 381.29 mi (613.63 km) |
| Columbus to Stow (Ohio) | 115.71 mi (186.21 km) |
| Columbus to Streamwood (Illinois) | 304.99 mi (490.84 km) |
| Columbus to Streator (Illinois) | 316.65 mi (509.59 km) |
| Columbus to Streetsboro (Ohio) | 122.05 mi (196.43 km) |
| Columbus to Strongsville (Ohio) | 109.83 mi (176.75 km) |
| Columbus to Stuart (Florida) | 897.56 mi (1,444.48 km) |
| Columbus to Stuarts Draft (Virginia) | 251.88 mi (405.36 km) |
| Columbus to Sturgis (Michigan) | 178.41 mi (287.13 km) |
| Columbus to Suamico (Wisconsin) | 412.90 mi (664.50 km) |
| Columbus to Sudley (Virginia) | 304.55 mi (490.12 km) |
| Columbus to Suffern (New York) | 470.55 mi (757.27 km) |
| Columbus to Suffolk (Virginia) | 412.09 mi (663.20 km) |
