| Columbus to Scottsboro (Alabama) | 405.63 mi (652.80 km) |
| Columbus to Scottsdale (Arizona) | 1,647.20 mi (2,650.91 km) |
| Columbus to Scranton (Pennsylvania) | 395.68 mi (636.78 km) |
| Columbus to Seabrook (Maryland) | 334.40 mi (538.17 km) |
| Columbus to Seabrook (Texas) | 990.16 mi (1,593.52 km) |
| Columbus to Seaford (New York) | 502.02 mi (807.92 km) |
| Columbus to Seagoville (Texas) | 907.53 mi (1,460.53 km) |
| Columbus to Seal Beach (California) | 1,973.16 mi (3,175.49 km) |
| Columbus to Searcy (Arkansas) | 579.87 mi (933.21 km) |
| Columbus to Seaside (California) | 2,101.70 mi (3,382.36 km) |
| Columbus to SeaTac (Washington) | 2,006.54 mi (3,229.22 km) |
| Columbus to Seattle (Washington) | 2,007.83 mi (3,231.29 km) |
| Columbus to Sebastian (Florida) | 855.25 mi (1,376.39 km) |
| Columbus to Sebring (Florida) | 868.73 mi (1,398.09 km) |
| Columbus to Secaucus (New Jersey) | 472.43 mi (760.30 km) |
