| Colonia to Southern Pines (North Carolina) | 464.78 mi (747.99 km) |
| Colonia to Southfield (Michigan) | 480.37 mi (773.08 km) |
| Colonia to Southgate (Michigan) | 473.83 mi (762.55 km) |
| Colonia to Southlake (Texas) | 1,364.46 mi (2,195.89 km) |
| Colonia to Spanaway (Washington) | 2,399.95 mi (3,862.34 km) |
| Colonia to Spanish Fork (Utah) | 1,950.76 mi (3,139.44 km) |
| Colonia to Spanish Lake (Missouri) | 852.93 mi (1,372.66 km) |
| Colonia to Spanish Springs (Nevada) | 2,370.09 mi (3,814.29 km) |
| Colonia to Sparks (Nevada) | 2,374.12 mi (3,820.77 km) |
| Colonia to Spartanburg (South Carolina) | 569.73 mi (916.89 km) |
| Colonia to Spearfish (South Dakota) | 1,517.18 mi (2,441.67 km) |
| Colonia to Speedway (Indiana) | 631.75 mi (1,016.70 km) |
| Colonia to Spencer (Iowa) | 1,083.69 mi (1,744.03 km) |
| Colonia to Spokane (Washington) | 2,163.93 mi (3,482.51 km) |
| Colonia to Spokane Valley (Washington) | 2,154.73 mi (3,467.70 km) |
