| Clute to Southern Pines (North Carolina) | 1,026.76 mi (1,652.41 km) |
| Clute to Southfield (Michigan) | 1,149.28 mi (1,849.59 km) |
| Clute to Southgate (Michigan) | 1,136.77 mi (1,829.46 km) |
| Clute to Southlake (Texas) | 290.62 mi (467.71 km) |
| Clute to Spanaway (Washington) | 1,911.56 mi (3,076.37 km) |
| Clute to Spanish Fork (Utah) | 1,196.78 mi (1,926.03 km) |
| Clute to Spanish Lake (Missouri) | 736.92 mi (1,185.96 km) |
| Clute to Spanish Springs (Nevada) | 1,560.29 mi (2,511.04 km) |
| Clute to Sparks (Nevada) | 1,560.60 mi (2,511.55 km) |
| Clute to Spartanburg (South Carolina) | 888.02 mi (1,429.14 km) |
| Clute to Spearfish (South Dakota) | 1,164.15 mi (1,873.52 km) |
| Clute to Speedway (Indiana) | 907.43 mi (1,460.37 km) |
| Clute to Spencer (Iowa) | 975.77 mi (1,570.36 km) |
| Clute to Spokane (Washington) | 1,743.98 mi (2,806.67 km) |
| Clute to Spokane Valley (Washington) | 1,736.70 mi (2,794.95 km) |
