| Clemson to Southern Pines (North Carolina) | 196.23 mi (315.80 km) |
| Clemson to Southfield (Michigan) | 538.97 mi (867.39 km) |
| Clemson to Southgate (Michigan) | 520.08 mi (837.00 km) |
| Clemson to Southlake (Texas) | 830.93 mi (1,337.25 km) |
| Clemson to Spanaway (Washington) | 2,210.68 mi (3,557.75 km) |
| Clemson to Spanish Fork (Utah) | 1,618.54 mi (2,604.79 km) |
| Clemson to Spanish Lake (Missouri) | 497.83 mi (801.19 km) |
| Clemson to Spanish Springs (Nevada) | 2,043.47 mi (3,288.65 km) |
| Clemson to Sparks (Nevada) | 2,046.18 mi (3,293.01 km) |
| Clemson to Spartanburg (South Carolina) | 53.45 mi (86.03 km) |
| Clemson to Spearfish (South Dakota) | 1,301.85 mi (2,095.12 km) |
| Clemson to Speedway (Indiana) | 400.38 mi (644.35 km) |
| Clemson to Spencer (Iowa) | 882.64 mi (1,420.47 km) |
| Clemson to Spokane (Washington) | 1,989.28 mi (3,201.44 km) |
| Clemson to Spokane Valley (Washington) | 1,980.26 mi (3,186.91 km) |
