| Clemson to Olympia Heights (Florida) | 636.36 mi (1,024.13 km) |
| Clemson to Omaha (Nebraska) | 851.00 mi (1,369.55 km) |
| Clemson to On Top of the World Designated Place (Florida) | 386.63 mi (622.21 km) |
| Clemson to Onalaska (Wisconsin) | 777.54 mi (1,251.33 km) |
| Clemson to Oneida (New York) | 695.23 mi (1,118.87 km) |
| Clemson to Oneonta (New York) | 680.09 mi (1,094.50 km) |
| Clemson to Ontario (California) | 1,975.04 mi (3,178.52 km) |
| Clemson to Ontario (Oregon) | 1,919.72 mi (3,089.49 km) |
| Clemson to Opa-locka (Florida) | 625.72 mi (1,007.01 km) |
| Clemson to Opelika (Alabama) | 203.14 mi (326.92 km) |
| Clemson to Opelousas (Louisiana) | 610.87 mi (983.10 km) |
| Clemson to Orange (California) | 1,990.39 mi (3,203.22 km) |
| Clemson to Orange (Texas) | 711.61 mi (1,145.22 km) |
| Clemson to Orange City (Florida) | 407.15 mi (655.25 km) |
| Clemson to Orangeburg (South Carolina) | 138.42 mi (222.76 km) |
