| Clemson to Enumclaw (Washington) | 2,191.61 mi (3,527.06 km) |
| Clemson to Ephrata (Pennsylvania) | 525.65 mi (845.95 km) |
| Clemson to Erie (Colorado) | 1,271.64 mi (2,046.50 km) |
| Clemson to Erie (Pennsylvania) | 534.47 mi (860.15 km) |
| Clemson to Erlanger (Kentucky) | 314.64 mi (506.36 km) |
| Clemson to Escanaba (Michigan) | 796.75 mi (1,282.24 km) |
| Clemson to Escondido (California) | 1,957.99 mi (3,151.09 km) |
| Clemson to Española (New Mexico) | 1,310.76 mi (2,109.46 km) |
| Clemson to Essex (Maryland) | 474.42 mi (763.51 km) |
| Clemson to Essex Junction (Vermont) | 850.60 mi (1,368.91 km) |
| Clemson to Estelle (Louisiana) | 541.17 mi (870.94 km) |
| Clemson to Estero (Florida) | 573.63 mi (923.17 km) |
| Clemson to Euclid (Ohio) | 482.33 mi (776.24 km) |
| Clemson to Eufaula (Alabama) | 234.40 mi (377.24 km) |
| Clemson to Eugene (Oregon) | 2,223.53 mi (3,578.43 km) |
