| Chicago to Eau Claire (Wisconsin) | 281.17 mi (452.49 km) |
| Chicago to Echelon (New Jersey) | 676.76 mi (1,089.14 km) |
| Chicago to Eden (North Carolina) | 562.58 mi (905.39 km) |
| Chicago to Eden Prairie (Minnesota) | 356.83 mi (574.27 km) |
| Chicago to Edgewater (Florida) | 966.69 mi (1,555.74 km) |
| Chicago to Edgewater (New Jersey) | 714.12 mi (1,149.27 km) |
| Chicago to Edgewood (Maryland) | 619.68 mi (997.28 km) |
| Chicago to Edgewood (Washington) | 1,729.17 mi (2,782.83 km) |
| Chicago to Edina (Minnesota) | 354.46 mi (570.44 km) |
| Chicago to Edinburg (Texas) | 1,226.07 mi (1,973.17 km) |
| Chicago to Edmond (Oklahoma) | 674.87 mi (1,086.09 km) |
| Chicago to Edmonds (Washington) | 1,732.60 mi (2,788.35 km) |
| Chicago to Edwards (Colorado) | 1,000.90 mi (1,610.79 km) |
| Chicago to Edwardsville (Illinois) | 242.80 mi (390.75 km) |
| Chicago to Effingham (Illinois) | 193.14 mi (310.83 km) |
