| Chicago to Eckington | 3,849.05 mi (6,194.44 km) |
| Chicago to Edgware | 3,942.53 mi (6,344.88 km) |
| Chicago to Edinburgh | 3,707.04 mi (5,965.90 km) |
| Chicago to Edmonton | 3,950.31 mi (6,357.41 km) |
| Chicago to Egg Buckland | 3,831.29 mi (6,165.87 km) |
| Chicago to Elgin | 3,658.08 mi (5,887.11 km) |
| Chicago to Elland | 3,820.22 mi (6,148.05 km) |
| Chicago to Ellesmere Port | 3,792.72 mi (6,103.79 km) |
| Chicago to Ellon | 3,707.73 mi (5,967.01 km) |
| Chicago to Eltham | 3,960.27 mi (6,373.43 km) |
| Chicago to Ely | 3,937.88 mi (6,337.41 km) |
| Chicago to Emsworth | 3,941.60 mi (6,343.39 km) |
| Chicago to Enfield | 3,948.75 mi (6,354.90 km) |
| Chicago to Enfield Lock | 3,950.31 mi (6,357.40 km) |
| Chicago to Englefield Green | 3,937.21 mi (6,336.32 km) |
