| Chattanooga to Southern Pines (North Carolina) | 330.31 mi (531.59 km) |
| Chattanooga to Southfield (Michigan) | 523.05 mi (841.76 km) |
| Chattanooga to Southgate (Michigan) | 505.36 mi (813.29 km) |
| Chattanooga to Southlake (Texas) | 696.66 mi (1,121.16 km) |
| Chattanooga to Spanaway (Washington) | 2,082.43 mi (3,351.34 km) |
| Chattanooga to Spanish Fork (Utah) | 1,480.49 mi (2,382.62 km) |
| Chattanooga to Spanish Lake (Missouri) | 375.63 mi (604.52 km) |
| Chattanooga to Spanish Springs (Nevada) | 1,904.81 mi (3,065.50 km) |
| Chattanooga to Sparks (Nevada) | 1,907.45 mi (3,069.75 km) |
| Chattanooga to Spartanburg (South Carolina) | 188.24 mi (302.95 km) |
| Chattanooga to Spearfish (South Dakota) | 1,177.22 mi (1,894.55 km) |
| Chattanooga to Speedway (Indiana) | 331.22 mi (533.05 km) |
| Chattanooga to Spencer (Iowa) | 769.47 mi (1,238.35 km) |
| Chattanooga to Spokane (Washington) | 1,863.73 mi (2,999.39 km) |
| Chattanooga to Spokane Valley (Washington) | 1,854.78 mi (2,984.98 km) |
