| Charlotte to Southern Pines (North Carolina) | 80.54 mi (129.62 km) |
| Charlotte to Southfield (Michigan) | 518.87 mi (835.04 km) |
| Charlotte to Southgate (Michigan) | 500.02 mi (804.71 km) |
| Charlotte to Southlake (Texas) | 945.70 mi (1,521.95 km) |
| Charlotte to Spanaway (Washington) | 2,282.67 mi (3,673.61 km) |
| Charlotte to Spanish Fork (Utah) | 1,709.99 mi (2,751.96 km) |
| Charlotte to Spanish Lake (Missouri) | 573.15 mi (922.39 km) |
| Charlotte to Spanish Springs (Nevada) | 2,136.15 mi (3,437.81 km) |
| Charlotte to Sparks (Nevada) | 2,139.06 mi (3,442.49 km) |
| Charlotte to Spartanburg (South Carolina) | 64.54 mi (103.86 km) |
| Charlotte to Spearfish (South Dakota) | 1,370.99 mi (2,206.39 km) |
| Charlotte to Speedway (Indiana) | 434.07 mi (698.56 km) |
| Charlotte to Spencer (Iowa) | 940.92 mi (1,514.26 km) |
| Charlotte to Spokane (Washington) | 2,057.60 mi (3,311.39 km) |
| Charlotte to Spokane Valley (Washington) | 2,048.49 mi (3,296.73 km) |
