| Charlotte to Scottsboro (Alabama) | 298.17 mi (479.85 km) |
| Charlotte to Scottsdale (Arizona) | 1,764.24 mi (2,839.26 km) |
| Charlotte to Scranton (Pennsylvania) | 511.34 mi (822.92 km) |
| Charlotte to Seabrook (Maryland) | 340.56 mi (548.08 km) |
| Charlotte to Seabrook (Texas) | 913.76 mi (1,470.56 km) |
| Charlotte to Seaford (New York) | 549.33 mi (884.06 km) |
| Charlotte to Seagoville (Texas) | 917.02 mi (1,475.80 km) |
| Charlotte to Seal Beach (California) | 2,111.00 mi (3,397.33 km) |
| Charlotte to Searcy (Arkansas) | 615.18 mi (990.04 km) |
| Charlotte to Seaside (California) | 2,278.25 mi (3,666.49 km) |
| Charlotte to SeaTac (Washington) | 2,279.41 mi (3,668.36 km) |
| Charlotte to Seattle (Washington) | 2,282.00 mi (3,672.53 km) |
| Charlotte to Sebastian (Florida) | 513.50 mi (826.40 km) |
| Charlotte to Sebring (Florida) | 535.44 mi (861.71 km) |
| Charlotte to Secaucus (New Jersey) | 532.50 mi (856.97 km) |
