| Charlotte to Olympia Heights (Florida) | 655.95 mi (1,055.65 km) |
| Charlotte to Omaha (Nebraska) | 924.20 mi (1,487.35 km) |
| Charlotte to On Top of the World Designated Place (Florida) | 430.14 mi (692.25 km) |
| Charlotte to Onalaska (Wisconsin) | 814.38 mi (1,310.62 km) |
| Charlotte to Oneida (New York) | 609.83 mi (981.42 km) |
| Charlotte to Oneonta (New York) | 588.67 mi (947.37 km) |
| Charlotte to Ontario (California) | 2,080.56 mi (3,348.33 km) |
| Charlotte to Ontario (Oregon) | 1,999.77 mi (3,218.32 km) |
| Charlotte to Opa-locka (Florida) | 644.07 mi (1,036.53 km) |
| Charlotte to Opelika (Alabama) | 314.43 mi (506.02 km) |
| Charlotte to Opelousas (Louisiana) | 728.09 mi (1,171.74 km) |
| Charlotte to Orange (California) | 2,096.26 mi (3,373.61 km) |
| Charlotte to Orange (Texas) | 829.21 mi (1,334.49 km) |
| Charlotte to Orange City (Florida) | 434.28 mi (698.91 km) |
| Charlotte to Orangeburg (South Carolina) | 118.55 mi (190.78 km) |
