| Chapel Hill to Superior (Colorado) | 1,444.70 mi (2,325.03 km) |
| Chapel Hill to Superior (Wisconsin) | 1,003.15 mi (1,614.42 km) |
| Chapel Hill to Surprise (Arizona) | 1,892.71 mi (3,046.03 km) |
| Chapel Hill to Susanville (California) | 2,258.45 mi (3,634.62 km) |
| Chapel Hill to Sussex (Wisconsin) | 697.37 mi (1,122.31 km) |
| Chapel Hill to Suwanee (Georgia) | 312.77 mi (503.35 km) |
| Chapel Hill to Swansea (Illinois) | 628.37 mi (1,011.27 km) |
| Chapel Hill to Sweetwater (Florida) | 705.65 mi (1,135.63 km) |
| Chapel Hill to Sweetwater (Texas) | 1,241.74 mi (1,998.38 km) |
| Chapel Hill to Sycamore (Illinois) | 665.74 mi (1,071.41 km) |
| Chapel Hill to Sylacauga (Alabama) | 452.55 mi (728.30 km) |
| Chapel Hill to Sylvania (Ohio) | 471.89 mi (759.43 km) |
| Chapel Hill to Syosset (New York) | 451.52 mi (726.65 km) |
| Chapel Hill to Syracuse (New York) | 515.09 mi (828.96 km) |
| Chapel Hill to Syracuse (Utah) | 1,809.82 mi (2,912.63 km) |
