| Chapel Hill to Storm Lake (Iowa) | 978.44 mi (1,574.64 km) |
| Chapel Hill to Storrs (Connecticut) | 545.94 mi (878.60 km) |
| Chapel Hill to Stoughton (Wisconsin) | 726.40 mi (1,169.03 km) |
| Chapel Hill to Stow (Ohio) | 385.05 mi (619.68 km) |
| Chapel Hill to Streamwood (Illinois) | 646.05 mi (1,039.71 km) |
| Chapel Hill to Streator (Illinois) | 638.91 mi (1,028.23 km) |
| Chapel Hill to Streetsboro (Ohio) | 387.58 mi (623.75 km) |
| Chapel Hill to Strongsville (Ohio) | 401.42 mi (646.03 km) |
| Chapel Hill to Stuart (Florida) | 607.41 mi (977.53 km) |
| Chapel Hill to Stuarts Draft (Virginia) | 144.52 mi (232.59 km) |
| Chapel Hill to Sturgis (Michigan) | 531.08 mi (854.68 km) |
| Chapel Hill to Suamico (Wisconsin) | 766.13 mi (1,232.97 km) |
| Chapel Hill to Sudley (Virginia) | 215.05 mi (346.08 km) |
| Chapel Hill to Suffern (New York) | 445.36 mi (716.74 km) |
| Chapel Hill to Suffolk (Virginia) | 143.74 mi (231.32 km) |
