| Chapel Hill to Southern Pines (North Carolina) | 54.73 mi (88.08 km) |
| Chapel Hill to Southfield (Michigan) | 505.65 mi (813.77 km) |
| Chapel Hill to Southgate (Michigan) | 487.78 mi (785.01 km) |
| Chapel Hill to Southlake (Texas) | 1,050.62 mi (1,690.81 km) |
| Chapel Hill to Spanaway (Washington) | 2,339.27 mi (3,764.69 km) |
| Chapel Hill to Spanish Fork (Utah) | 1,787.71 mi (2,877.05 km) |
| Chapel Hill to Spanish Lake (Missouri) | 643.94 mi (1,036.32 km) |
| Chapel Hill to Spanish Springs (Nevada) | 2,214.39 mi (3,563.72 km) |
| Chapel Hill to Sparks (Nevada) | 2,217.51 mi (3,568.74 km) |
| Chapel Hill to Spartanburg (South Carolina) | 176.08 mi (283.37 km) |
| Chapel Hill to Spearfish (South Dakota) | 1,427.61 mi (2,297.52 km) |
| Chapel Hill to Speedway (Indiana) | 475.16 mi (764.69 km) |
| Chapel Hill to Spencer (Iowa) | 990.55 mi (1,594.13 km) |
| Chapel Hill to Spokane (Washington) | 2,111.01 mi (3,397.33 km) |
| Chapel Hill to Spokane Valley (Washington) | 2,101.83 mi (3,382.57 km) |
