| Chapel Hill to Scottsboro (Alabama) | 405.08 mi (651.92 km) |
| Chapel Hill to Scottsdale (Arizona) | 1,859.93 mi (2,993.28 km) |
| Chapel Hill to Scranton (Pennsylvania) | 419.86 mi (675.69 km) |
| Chapel Hill to Seabrook (Maryland) | 242.70 mi (390.59 km) |
| Chapel Hill to Seabrook (Texas) | 1,025.54 mi (1,650.45 km) |
| Chapel Hill to Seaford (New York) | 444.50 mi (715.36 km) |
| Chapel Hill to Seagoville (Texas) | 1,023.11 mi (1,646.53 km) |
| Chapel Hill to Seal Beach (California) | 2,203.84 mi (3,546.74 km) |
| Chapel Hill to Searcy (Arkansas) | 714.46 mi (1,149.82 km) |
| Chapel Hill to Seaside (California) | 2,363.39 mi (3,803.50 km) |
| Chapel Hill to SeaTac (Washington) | 2,334.92 mi (3,757.69 km) |
| Chapel Hill to Seattle (Washington) | 2,336.97 mi (3,760.99 km) |
| Chapel Hill to Sebastian (Florida) | 569.07 mi (915.83 km) |
| Chapel Hill to Sebring (Florida) | 600.78 mi (966.86 km) |
| Chapel Hill to Secaucus (New Jersey) | 430.05 mi (692.09 km) |
