| Chapel Hill to Oswego (Illinois) | 638.74 mi (1,027.95 km) |
| Chapel Hill to Oswego (New York) | 537.05 mi (864.30 km) |
| Chapel Hill to Otsego (Minnesota) | 998.01 mi (1,606.15 km) |
| Chapel Hill to Ottawa (Illinois) | 647.12 mi (1,041.44 km) |
| Chapel Hill to Ottawa (Kansas) | 909.78 mi (1,464.15 km) |
| Chapel Hill to Ottumwa (Iowa) | 803.54 mi (1,293.17 km) |
| Chapel Hill to Overland (Missouri) | 650.84 mi (1,047.42 km) |
| Chapel Hill to Overland Park (Kansas) | 881.61 mi (1,418.81 km) |
| Chapel Hill to Overlea (Maryland) | 274.61 mi (441.94 km) |
| Chapel Hill to Oviedo (Florida) | 517.63 mi (833.05 km) |
| Chapel Hill to Owasso (Oklahoma) | 936.51 mi (1,507.17 km) |
| Chapel Hill to Owatonna (Minnesota) | 937.08 mi (1,508.09 km) |
| Chapel Hill to Owensboro (Kentucky) | 464.06 mi (746.83 km) |
| Chapel Hill to Owings Mills (Maryland) | 270.29 mi (435.00 km) |
| Chapel Hill to Owosso (Michigan) | 559.73 mi (900.79 km) |
