| Chapel Hill to Orangevale (California) | 2,305.58 mi (3,710.48 km) |
| Chapel Hill to Orchards (Washington) | 2,340.70 mi (3,766.99 km) |
| Chapel Hill to Orcutt (California) | 2,314.25 mi (3,724.43 km) |
| Chapel Hill to Oregon (Ohio) | 460.77 mi (741.54 km) |
| Chapel Hill to Oregon (Wisconsin) | 733.11 mi (1,179.83 km) |
| Chapel Hill to Oregon City (Oregon) | 2,343.35 mi (3,771.26 km) |
| Chapel Hill to Orem (Utah) | 1,790.59 mi (2,881.67 km) |
| Chapel Hill to Orinda (California) | 2,366.02 mi (3,807.74 km) |
| Chapel Hill to Orland Park (Illinois) | 615.82 mi (991.06 km) |
| Chapel Hill to Orlando (Florida) | 531.92 mi (856.05 km) |
| Chapel Hill to Ormond Beach (Florida) | 473.42 mi (761.90 km) |
| Chapel Hill to Oro Valley (Arizona) | 1,833.44 mi (2,950.64 km) |
| Chapel Hill to Oroville (California) | 2,315.82 mi (3,726.95 km) |
| Chapel Hill to Oshkosh (Wisconsin) | 752.03 mi (1,210.27 km) |
| Chapel Hill to Oskaloosa (Iowa) | 821.30 mi (1,321.75 km) |
