| Chapel Hill to Olympia Heights (Florida) | 709.15 mi (1,141.26 km) |
| Chapel Hill to Omaha (Nebraska) | 987.85 mi (1,589.79 km) |
| Chapel Hill to On Top of the World Designated Place (Florida) | 507.77 mi (817.18 km) |
| Chapel Hill to Onalaska (Wisconsin) | 846.04 mi (1,361.57 km) |
| Chapel Hill to Oneida (New York) | 525.66 mi (845.97 km) |
| Chapel Hill to Oneonta (New York) | 498.54 mi (802.32 km) |
| Chapel Hill to Ontario (California) | 2,173.00 mi (3,497.11 km) |
| Chapel Hill to Ontario (Oregon) | 2,065.13 mi (3,323.51 km) |
| Chapel Hill to Opa-locka (Florida) | 696.55 mi (1,120.98 km) |
| Chapel Hill to Opelika (Alabama) | 426.23 mi (685.95 km) |
| Chapel Hill to Opelousas (Louisiana) | 840.15 mi (1,352.09 km) |
| Chapel Hill to Orange (California) | 2,189.11 mi (3,523.03 km) |
| Chapel Hill to Orange (Texas) | 941.04 mi (1,514.45 km) |
| Chapel Hill to Orange City (Florida) | 500.56 mi (805.57 km) |
| Chapel Hill to Orangeburg (South Carolina) | 197.65 mi (318.08 km) |
