| Champaign to Southern Pines (North Carolina) | 592.00 mi (952.74 km) |
| Champaign to Southfield (Michigan) | 307.11 mi (494.24 km) |
| Champaign to Southgate (Michigan) | 300.53 mi (483.66 km) |
| Champaign to Southlake (Texas) | 697.54 mi (1,122.57 km) |
| Champaign to Spanaway (Washington) | 1,759.77 mi (2,832.08 km) |
| Champaign to Spanish Fork (Utah) | 1,231.15 mi (1,981.35 km) |
| Champaign to Spanish Lake (Missouri) | 137.97 mi (222.04 km) |
| Champaign to Spanish Springs (Nevada) | 1,656.10 mi (2,665.23 km) |
| Champaign to Sparks (Nevada) | 1,659.67 mi (2,670.98 km) |
| Champaign to Spartanburg (South Carolina) | 498.33 mi (801.99 km) |
| Champaign to Spearfish (South Dakota) | 848.17 mi (1,364.99 km) |
| Champaign to Speedway (Indiana) | 109.54 mi (176.29 km) |
| Champaign to Spencer (Iowa) | 412.27 mi (663.49 km) |
| Champaign to Spokane (Washington) | 1,531.94 mi (2,465.42 km) |
| Champaign to Spokane Valley (Washington) | 1,522.78 mi (2,450.67 km) |
