| Champaign to Scottsboro (Alabama) | 397.17 mi (639.19 km) |
| Champaign to Scottsdale (Arizona) | 1,372.12 mi (2,208.22 km) |
| Champaign to Scranton (Pennsylvania) | 665.27 mi (1,070.65 km) |
| Champaign to Seabrook (Maryland) | 613.21 mi (986.86 km) |
| Champaign to Seabrook (Texas) | 821.99 mi (1,322.87 km) |
| Champaign to Seaford (New York) | 777.89 mi (1,251.89 km) |
| Champaign to Seagoville (Texas) | 690.33 mi (1,110.98 km) |
| Champaign to Seal Beach (California) | 1,694.54 mi (2,727.10 km) |
| Champaign to Searcy (Arkansas) | 386.13 mi (621.42 km) |
| Champaign to Seaside (California) | 1,822.28 mi (2,932.68 km) |
| Champaign to SeaTac (Washington) | 1,755.50 mi (2,825.21 km) |
| Champaign to Seattle (Washington) | 1,757.62 mi (2,828.62 km) |
| Champaign to Sebastian (Florida) | 961.01 mi (1,546.59 km) |
| Champaign to Sebring (Florida) | 956.16 mi (1,538.79 km) |
| Champaign to Secaucus (New Jersey) | 747.65 mi (1,203.22 km) |
