| Champaign to Enumclaw (Washington) | 1,739.89 mi (2,800.08 km) |
| Champaign to Ephrata (Pennsylvania) | 638.17 mi (1,027.04 km) |
| Champaign to Erie (Colorado) | 885.10 mi (1,424.44 km) |
| Champaign to Erie (Pennsylvania) | 448.51 mi (721.80 km) |
| Champaign to Erlanger (Kentucky) | 210.66 mi (339.03 km) |
| Champaign to Escanaba (Michigan) | 393.80 mi (633.76 km) |
| Champaign to Escondido (California) | 1,659.81 mi (2,671.21 km) |
| Champaign to Española (New Mexico) | 1,006.87 mi (1,620.41 km) |
| Champaign to Essex (Maryland) | 630.78 mi (1,015.14 km) |
| Champaign to Essex Junction (Vermont) | 830.03 mi (1,335.80 km) |
| Champaign to Estelle (Louisiana) | 717.01 mi (1,153.92 km) |
| Champaign to Estero (Florida) | 1,016.24 mi (1,635.48 km) |
| Champaign to Euclid (Ohio) | 367.35 mi (591.19 km) |
| Champaign to Eufaula (Alabama) | 592.99 mi (954.33 km) |
| Champaign to Eugene (Oregon) | 1,793.68 mi (2,886.65 km) |
