| Champaign to Emeryville (California) | 1,822.92 mi (2,933.70 km) |
| Champaign to Emmaus (Pennsylvania) | 673.02 mi (1,083.12 km) |
| Champaign to Emporia (Kansas) | 439.70 mi (707.63 km) |
| Champaign to Encinitas (California) | 1,672.21 mi (2,691.16 km) |
| Champaign to Endicott (New York) | 649.66 mi (1,045.52 km) |
| Champaign to Endwell (New York) | 651.99 mi (1,049.27 km) |
| Champaign to Englewood (Colorado) | 885.82 mi (1,425.59 km) |
| Champaign to Englewood (Florida) | 969.34 mi (1,560.01 km) |
| Champaign to Englewood (New Jersey) | 752.36 mi (1,210.80 km) |
| Champaign to Englewood (Ohio) | 210.68 mi (339.05 km) |
| Champaign to Enid (Oklahoma) | 579.80 mi (933.10 km) |
| Champaign to Ennis (Texas) | 711.20 mi (1,144.57 km) |
| Champaign to Ensley (Florida) | 664.87 mi (1,070.00 km) |
| Champaign to Enterprise (Alabama) | 622.11 mi (1,001.19 km) |
| Champaign to Enterprise (Nevada) | 1,487.51 mi (2,393.91 km) |
