| Calexico to Southern Pines (North Carolina) | 2,064.73 mi (3,322.87 km) |
| Calexico to Southfield (Michigan) | 1,876.37 mi (3,019.72 km) |
| Calexico to Southgate (Michigan) | 1,875.82 mi (3,018.84 km) |
| Calexico to Southlake (Texas) | 1,063.96 mi (1,712.28 km) |
| Calexico to Spanaway (Washington) | 1,060.35 mi (1,706.47 km) |
| Calexico to Spanish Fork (Utah) | 555.85 mi (894.55 km) |
| Calexico to Spanish Lake (Missouri) | 1,474.09 mi (2,372.31 km) |
| Calexico to Spanish Springs (Nevada) | 534.87 mi (860.80 km) |
| Calexico to Sparks (Nevada) | 530.91 mi (854.41 km) |
| Calexico to Spartanburg (South Carolina) | 1,924.38 mi (3,097.00 km) |
| Calexico to Spearfish (South Dakota) | 1,028.87 mi (1,655.81 km) |
| Calexico to Speedway (Indiana) | 1,693.58 mi (2,725.55 km) |
| Calexico to Spencer (Iowa) | 1,318.06 mi (2,121.22 km) |
| Calexico to Spokane (Washington) | 1,040.13 mi (1,673.92 km) |
| Calexico to Spokane Valley (Washington) | 1,038.86 mi (1,671.88 km) |
