| Cahokia to Southern Pines (North Carolina) | 638.98 mi (1,028.35 km) |
| Cahokia to Southfield (Michigan) | 452.62 mi (728.42 km) |
| Cahokia to Southgate (Michigan) | 444.67 mi (715.62 km) |
| Cahokia to Southlake (Texas) | 550.14 mi (885.37 km) |
| Cahokia to Spanaway (Washington) | 1,722.29 mi (2,771.76 km) |
| Cahokia to Spanish Fork (Utah) | 1,149.00 mi (1,849.14 km) |
| Cahokia to Spanish Lake (Missouri) | 15.51 mi (24.96 km) |
| Cahokia to Spanish Springs (Nevada) | 1,575.69 mi (2,535.83 km) |
| Cahokia to Sparks (Nevada) | 1,578.85 mi (2,540.91 km) |
| Cahokia to Spartanburg (South Carolina) | 520.64 mi (837.88 km) |
| Cahokia to Spearfish (South Dakota) | 814.02 mi (1,310.03 km) |
| Cahokia to Speedway (Indiana) | 227.00 mi (365.32 km) |
| Cahokia to Spencer (Iowa) | 409.45 mi (658.95 km) |
| Cahokia to Spokane (Washington) | 1,501.24 mi (2,416.02 km) |
| Cahokia to Spokane Valley (Washington) | 1,492.24 mi (2,401.53 km) |
