| Buffalo to Yonkers (New York) | 289.46 mi (465.84 km) |
| Buffalo to Yorba Linda (California) | 2,176.32 mi (3,502.45 km) |
| Buffalo to York (Pennsylvania) | 230.63 mi (371.16 km) |
| Buffalo to Yorktown (Indiana) | 392.31 mi (631.36 km) |
| Buffalo to Yorkville (Illinois) | 498.06 mi (801.54 km) |
| Buffalo to Youngstown (Ohio) | 155.01 mi (249.46 km) |
| Buffalo to Youngsville (Louisiana) | 1,144.29 mi (1,841.56 km) |
| Buffalo to Ypsilanti (Michigan) | 246.99 mi (397.50 km) |
| Buffalo to Yuba City (California) | 2,221.63 mi (3,575.36 km) |
| Buffalo to Yucaipa (California) | 2,134.80 mi (3,435.63 km) |
| Buffalo to Yucca Valley (California) | 2,100.51 mi (3,380.44 km) |
| Buffalo to Yukon (Oklahoma) | 1,130.28 mi (1,819.02 km) |
| Buffalo to Yulee (Florida) | 860.68 mi (1,385.12 km) |
| Buffalo to Yuma (Arizona) | 2,057.84 mi (3,311.77 km) |
| Buffalo to Zachary (Louisiana) | 1,083.48 mi (1,743.69 km) |
