| Buffalo to Worthington (Ohio) | 290.15 mi (466.95 km) |
| Buffalo to Wright (Florida) | 961.92 mi (1,548.05 km) |
| Buffalo to Wyandanch (New York) | 319.09 mi (513.52 km) |
| Buffalo to Wyandotte (Michigan) | 224.31 mi (361.00 km) |
| Buffalo to Wylie (Texas) | 1,175.35 mi (1,891.54 km) |
| Buffalo to Wyndham (Virginia) | 365.77 mi (588.65 km) |
| Buffalo to Wyoming (Michigan) | 347.03 mi (558.49 km) |
| Buffalo to Wyomissing (Pennsylvania) | 231.57 mi (372.68 km) |
| Buffalo to Xenia (Ohio) | 345.36 mi (555.81 km) |
| Buffalo to Yakima (Washington) | 2,038.02 mi (3,279.88 km) |
| Buffalo to Yankton (South Dakota) | 936.74 mi (1,507.53 km) |
| Buffalo to Yauco (Puerto Rico) | 1,856.01 mi (2,986.95 km) |
| Buffalo to Yazoo City (Mississippi) | 935.50 mi (1,505.55 km) |
| Buffalo to Yeadon (Pennsylvania) | 277.08 mi (445.92 km) |
| Buffalo to Yelm (Washington) | 2,131.67 mi (3,430.59 km) |
