| Buffalo to University Place (Washington) | 2,125.12 mi (3,420.06 km) |
| Buffalo to Upland (California) | 2,163.27 mi (3,481.44 km) |
| Buffalo to Upper Arlington (Ohio) | 295.27 mi (475.19 km) |
| Buffalo to Upper Grand Lagoon (Florida) | 958.49 mi (1,542.53 km) |
| Buffalo to Upper Montclair (New Jersey) | 278.18 mi (447.68 km) |
| Buffalo to Urbana (Illinois) | 520.38 mi (837.47 km) |
| Buffalo to Urbana (Maryland) | 259.10 mi (416.99 km) |
| Buffalo to Urbana (Ohio) | 318.77 mi (513.01 km) |
| Buffalo to Urbandale (Iowa) | 767.40 mi (1,235.02 km) |
| Buffalo to Utica (New York) | 183.54 mi (295.37 km) |
| Buffalo to Uvalde (Texas) | 1,496.23 mi (2,407.95 km) |
| Buffalo to Vacaville (California) | 2,257.70 mi (3,633.42 km) |
| Buffalo to Vadnais Heights (Minnesota) | 721.80 mi (1,161.62 km) |
| Buffalo to Vail (Arizona) | 1,886.91 mi (3,036.69 km) |
| Buffalo to Valdosta (Georgia) | 867.59 mi (1,396.25 km) |
