| Buffalo to Superior (Colorado) | 1,372.81 mi (2,209.32 km) |
| Buffalo to Superior (Wisconsin) | 698.63 mi (1,124.34 km) |
| Buffalo to Surprise (Arizona) | 1,915.37 mi (3,082.49 km) |
| Buffalo to Susanville (California) | 2,140.47 mi (3,444.76 km) |
| Buffalo to Sussex (Wisconsin) | 473.56 mi (762.13 km) |
| Buffalo to Suwanee (Georgia) | 673.22 mi (1,083.44 km) |
| Buffalo to Swansea (Illinois) | 655.34 mi (1,054.66 km) |
| Buffalo to Sweetwater (Florida) | 1,186.25 mi (1,909.09 km) |
| Buffalo to Sweetwater (Texas) | 1,375.68 mi (2,213.94 km) |
| Buffalo to Sycamore (Illinois) | 504.93 mi (812.61 km) |
| Buffalo to Sylacauga (Alabama) | 782.85 mi (1,259.88 km) |
| Buffalo to Sylvania (Ohio) | 261.61 mi (421.03 km) |
| Buffalo to Syosset (New York) | 310.52 mi (499.74 km) |
| Buffalo to Syracuse (New York) | 137.08 mi (220.61 km) |
| Buffalo to Syracuse (Utah) | 1,699.46 mi (2,735.02 km) |
