| Buffalo to Storm Lake (Iowa) | 828.00 mi (1,332.53 km) |
| Buffalo to Storrs (Connecticut) | 345.12 mi (555.42 km) |
| Buffalo to Stoughton (Wisconsin) | 524.62 mi (844.29 km) |
| Buffalo to Stow (Ohio) | 178.35 mi (287.03 km) |
| Buffalo to Streamwood (Illinois) | 479.16 mi (771.13 km) |
| Buffalo to Streator (Illinois) | 526.54 mi (847.38 km) |
| Buffalo to Streetsboro (Ohio) | 172.00 mi (276.81 km) |
| Buffalo to Strongsville (Ohio) | 188.20 mi (302.88 km) |
| Buffalo to Stuart (Florida) | 1,088.00 mi (1,750.96 km) |
| Buffalo to Stuarts Draft (Virginia) | 337.53 mi (543.19 km) |
| Buffalo to Sturgis (Michigan) | 343.91 mi (553.47 km) |
| Buffalo to Suamico (Wisconsin) | 475.06 mi (764.53 km) |
| Buffalo to Sudley (Virginia) | 292.90 mi (471.37 km) |
| Buffalo to Suffern (New York) | 271.32 mi (436.65 km) |
| Buffalo to Suffolk (Virginia) | 444.52 mi (715.39 km) |
