| Buffalo to Stephenville (Texas) | 1,287.62 mi (2,072.23 km) |
| Buffalo to Sterling (Colorado) | 1,260.04 mi (2,027.83 km) |
| Buffalo to Sterling (Illinois) | 558.68 mi (899.10 km) |
| Buffalo to Sterling (Virginia) | 279.56 mi (449.90 km) |
| Buffalo to Sterling Heights (Michigan) | 213.33 mi (343.33 km) |
| Buffalo to Steubenville (Ohio) | 198.45 mi (319.37 km) |
| Buffalo to Stevens Point (Wisconsin) | 545.67 mi (878.17 km) |
| Buffalo to Stevenson Ranch (California) | 2,201.46 mi (3,542.90 km) |
| Buffalo to Stillwater (Minnesota) | 710.00 mi (1,142.64 km) |
| Buffalo to Stillwater (Oklahoma) | 1,075.14 mi (1,730.27 km) |
| Buffalo to Stockbridge (Georgia) | 710.26 mi (1,143.05 km) |
| Buffalo to Stockton (California) | 2,234.66 mi (3,596.34 km) |
| Buffalo to Stone Ridge (Virginia) | 282.64 mi (454.86 km) |
| Buffalo to Stonecrest (Georgia) | 698.08 mi (1,123.46 km) |
| Buffalo to Stony Brook (New York) | 324.81 mi (522.73 km) |
