| Buffalo to St. Simons (Georgia) | 821.95 mi (1,322.80 km) |
| Buffalo to Stafford (Texas) | 1,302.38 mi (2,095.97 km) |
| Buffalo to Stallings (North Carolina) | 547.11 mi (880.50 km) |
| Buffalo to Stamford (Connecticut) | 298.60 mi (480.56 km) |
| Buffalo to Stanford (California) | 2,292.61 mi (3,689.60 km) |
| Buffalo to Stanton (California) | 2,190.45 mi (3,525.18 km) |
| Buffalo to Star (Idaho) | 1,877.18 mi (3,021.03 km) |
| Buffalo to Starkville (Mississippi) | 846.86 mi (1,362.89 km) |
| Buffalo to State College (Pennsylvania) | 154.52 mi (248.68 km) |
| Buffalo to Staten Island (New York) | 290.35 mi (467.28 km) |
| Buffalo to Statesboro (Georgia) | 740.38 mi (1,191.53 km) |
| Buffalo to Statesville (North Carolina) | 503.47 mi (810.25 km) |
| Buffalo to Staunton (Virginia) | 327.86 mi (527.65 km) |
| Buffalo to Steamboat Springs (Colorado) | 1,446.37 mi (2,327.71 km) |
| Buffalo to Steiner Ranch (Texas) | 1,360.16 mi (2,188.96 km) |
