| Buffalo to Southern Pines (North Carolina) | 533.48 mi (858.55 km) |
| Buffalo to Southfield (Michigan) | 225.95 mi (363.63 km) |
| Buffalo to Southgate (Michigan) | 226.90 mi (365.16 km) |
| Buffalo to Southlake (Texas) | 1,207.04 mi (1,942.55 km) |
| Buffalo to Spanaway (Washington) | 2,120.59 mi (3,412.75 km) |
| Buffalo to Spanish Fork (Utah) | 1,696.84 mi (2,730.80 km) |
| Buffalo to Spanish Lake (Missouri) | 657.48 mi (1,058.11 km) |
| Buffalo to Spanish Springs (Nevada) | 2,110.54 mi (3,396.58 km) |
| Buffalo to Sparks (Nevada) | 2,114.81 mi (3,403.46 km) |
| Buffalo to Spartanburg (South Carolina) | 574.03 mi (923.82 km) |
| Buffalo to Spearfish (South Dakota) | 1,247.16 mi (2,007.12 km) |
| Buffalo to Speedway (Indiana) | 439.56 mi (707.40 km) |
| Buffalo to Spencer (Iowa) | 822.45 mi (1,323.61 km) |
| Buffalo to Spokane (Washington) | 1,884.24 mi (3,032.38 km) |
| Buffalo to Spokane Valley (Washington) | 1,875.05 mi (3,017.61 km) |
