| Buffalo to Smyrna (Delaware) | 300.98 mi (484.38 km) |
| Buffalo to Smyrna (Georgia) | 695.45 mi (1,119.22 km) |
| Buffalo to Smyrna (Tennessee) | 629.77 mi (1,013.52 km) |
| Buffalo to Snellville (Georgia) | 684.17 mi (1,101.07 km) |
| Buffalo to Snoqualmie (Washington) | 2,089.49 mi (3,362.71 km) |
| Buffalo to Snyder (Texas) | 1,388.73 mi (2,234.94 km) |
| Buffalo to Socastee (South Carolina) | 636.73 mi (1,024.72 km) |
| Buffalo to Socorro (Texas) | 1,685.55 mi (2,712.63 km) |
| Buffalo to Soddy-Daisy (Tennessee) | 627.32 mi (1,009.57 km) |
| Buffalo to Solana Beach (California) | 2,180.27 mi (3,508.81 km) |
| Buffalo to Soledad (California) | 2,278.56 mi (3,666.98 km) |
| Buffalo to Solon (Ohio) | 169.06 mi (272.07 km) |
| Buffalo to Somers Point (New Jersey) | 331.76 mi (533.92 km) |
| Buffalo to Somerset (Kentucky) | 504.35 mi (811.67 km) |
| Buffalo to Somerset (New Jersey) | 278.59 mi (448.34 km) |
