| Buffalo to Silver Firs (Washington) | 2,100.85 mi (3,380.99 km) |
| Buffalo to Silver Spring (Maryland) | 285.76 mi (459.89 km) |
| Buffalo to Silver Springs Shores (Florida) | 968.83 mi (1,559.19 km) |
| Buffalo to Silverdale (Washington) | 2,127.13 mi (3,423.29 km) |
| Buffalo to Silverton (Oregon) | 2,163.16 mi (3,481.28 km) |
| Buffalo to Simi Valley (California) | 2,213.52 mi (3,562.32 km) |
| Buffalo to Simpsonville (South Carolina) | 593.62 mi (955.34 km) |
| Buffalo to Sioux City (Iowa) | 889.56 mi (1,431.60 km) |
| Buffalo to Sioux Falls (South Dakota) | 899.72 mi (1,447.95 km) |
| Buffalo to Skokie (Illinois) | 456.87 mi (735.26 km) |
| Buffalo to Sleepy Hollow (New York) | 284.38 mi (457.66 km) |
| Buffalo to Slidell (Louisiana) | 1,059.73 mi (1,705.47 km) |
| Buffalo to Smithfield (North Carolina) | 511.19 mi (822.68 km) |
| Buffalo to Smithfield (Utah) | 1,674.26 mi (2,694.47 km) |
| Buffalo to Smithville (Missouri) | 851.92 mi (1,371.03 km) |
