| Buffalo to Seymour (Tennessee) | 551.53 mi (887.60 km) |
| Buffalo to Shady Hills (Florida) | 1,022.69 mi (1,645.86 km) |
| Buffalo to Shafter (California) | 2,198.65 mi (3,538.38 km) |
| Buffalo to Shaker Heights (Ohio) | 169.82 mi (273.31 km) |
| Buffalo to Shakopee (Minnesota) | 739.37 mi (1,189.91 km) |
| Buffalo to Sharon (Pennsylvania) | 143.00 mi (230.14 km) |
| Buffalo to Sharonville (Ohio) | 382.35 mi (615.33 km) |
| Buffalo to Shasta Lake (California) | 2,222.57 mi (3,576.88 km) |
| Buffalo to Shawnee (Kansas) | 873.32 mi (1,405.47 km) |
| Buffalo to Shawnee (Oklahoma) | 1,098.93 mi (1,768.55 km) |
| Buffalo to Sheboygan (Wisconsin) | 450.03 mi (724.26 km) |
| Buffalo to Shelby (North Carolina) | 545.33 mi (877.62 km) |
| Buffalo to Shelbyville (Indiana) | 428.55 mi (689.69 km) |
| Buffalo to Shelbyville (Kentucky) | 466.03 mi (749.99 km) |
| Buffalo to Shelbyville (Tennessee) | 653.12 mi (1,051.10 km) |
