| Buffalo to Security-Widefield (Colorado) | 1,376.65 mi (2,215.50 km) |
| Buffalo to Sedalia (Missouri) | 804.98 mi (1,295.49 km) |
| Buffalo to Sedro-Woolley (Washington) | 2,099.60 mi (3,378.97 km) |
| Buffalo to Seguin (Texas) | 1,401.42 mi (2,255.36 km) |
| Buffalo to Selden (New York) | 329.67 mi (530.56 km) |
| Buffalo to Selma (Alabama) | 850.64 mi (1,368.97 km) |
| Buffalo to Selma (California) | 2,187.52 mi (3,520.48 km) |
| Buffalo to Selma (Texas) | 1,415.97 mi (2,278.78 km) |
| Buffalo to Seminole (Florida) | 1,063.45 mi (1,711.46 km) |
| Buffalo to Seven Hills (Ohio) | 178.86 mi (287.85 km) |
| Buffalo to Seven Oaks (South Carolina) | 624.17 mi (1,004.50 km) |
| Buffalo to Severn (Maryland) | 283.37 mi (456.05 km) |
| Buffalo to Severna Park (Maryland) | 289.12 mi (465.30 km) |
| Buffalo to Sevierville (Tennessee) | 546.02 mi (878.73 km) |
| Buffalo to Seymour (Indiana) | 457.78 mi (736.72 km) |
