| Buffalo to Scottsboro (Alabama) | 689.31 mi (1,109.34 km) |
| Buffalo to Scottsdale (Arizona) | 1,885.81 mi (3,034.92 km) |
| Buffalo to Scranton (Pennsylvania) | 193.11 mi (310.78 km) |
| Buffalo to Seabrook (Maryland) | 290.31 mi (467.22 km) |
| Buffalo to Seabrook (Texas) | 1,284.08 mi (2,066.52 km) |
| Buffalo to Seaford (New York) | 316.11 mi (508.73 km) |
| Buffalo to Seagoville (Texas) | 1,194.01 mi (1,921.58 km) |
| Buffalo to Seal Beach (California) | 2,195.90 mi (3,533.95 km) |
| Buffalo to Searcy (Arkansas) | 868.91 mi (1,398.37 km) |
| Buffalo to Seaside (California) | 2,297.53 mi (3,697.51 km) |
| Buffalo to SeaTac (Washington) | 2,111.43 mi (3,398.02 km) |
| Buffalo to Seattle (Washington) | 2,111.00 mi (3,397.33 km) |
| Buffalo to Sebastian (Florida) | 1,048.65 mi (1,687.64 km) |
| Buffalo to Sebring (Florida) | 1,075.70 mi (1,731.17 km) |
| Buffalo to Secaucus (New Jersey) | 286.43 mi (460.97 km) |
