| Buffalo to Savannah (Georgia) | 762.00 mi (1,226.31 km) |
| Buffalo to Sayreville (New Jersey) | 287.77 mi (463.12 km) |
| Buffalo to Sayville (New York) | 331.93 mi (534.19 km) |
| Buffalo to Scaggsville (Maryland) | 279.23 mi (449.38 km) |
| Buffalo to Scarsdale (New York) | 292.11 mi (470.10 km) |
| Buffalo to Schaumburg (Illinois) | 474.28 mi (763.28 km) |
| Buffalo to Schenectady (New York) | 249.33 mi (401.26 km) |
| Buffalo to Schererville (Indiana) | 450.52 mi (725.04 km) |
| Buffalo to Schertz (Texas) | 1,414.54 mi (2,276.48 km) |
| Buffalo to Schiller Park (Illinois) | 464.39 mi (747.37 km) |
| Buffalo to Schofield Barracks (Hawaii) | 4,688.18 mi (7,544.89 km) |
| Buffalo to Scotchtown (New York) | 249.64 mi (401.76 km) |
| Buffalo to Scottdale (Georgia) | 693.87 mi (1,116.68 km) |
| Buffalo to Scotts Valley (California) | 2,294.98 mi (3,693.42 km) |
| Buffalo to Scottsbluff (Nebraska) | 1,263.73 mi (2,033.78 km) |
