| Buffalo to Santa Rosa (California) | 2,292.58 mi (3,689.55 km) |
| Buffalo to Santaquin (Utah) | 1,707.48 mi (2,747.93 km) |
| Buffalo to Santee (California) | 2,171.31 mi (3,494.39 km) |
| Buffalo to Sapulpa (Oklahoma) | 1,033.51 mi (1,663.27 km) |
| Buffalo to Saraland (Alabama) | 975.86 mi (1,570.50 km) |
| Buffalo to Sarasota (Florida) | 1,095.08 mi (1,762.36 km) |
| Buffalo to Sarasota Springs (Florida) | 1,096.40 mi (1,764.49 km) |
| Buffalo to Saratoga (California) | 2,289.81 mi (3,685.09 km) |
| Buffalo to Saratoga Springs (New York) | 256.54 mi (412.86 km) |
| Buffalo to Saratoga Springs (Utah) | 1,705.92 mi (2,745.42 km) |
| Buffalo to Sartell (Minnesota) | 782.12 mi (1,258.70 km) |
| Buffalo to Satellite Beach (Florida) | 1,022.00 mi (1,644.75 km) |
| Buffalo to Sauk Rapids (Minnesota) | 778.72 mi (1,253.23 km) |
| Buffalo to Sault Ste. Marie (Michigan) | 366.97 mi (590.58 km) |
| Buffalo to Savage (Minnesota) | 733.68 mi (1,180.75 km) |
