| Buffalo to Sanford (Maine) | 409.22 mi (658.57 km) |
| Buffalo to Sanford (North Carolina) | 512.58 mi (824.92 km) |
| Buffalo to Sanger (California) | 2,181.04 mi (3,510.04 km) |
| Buffalo to Santa Ana (California) | 2,186.90 mi (3,519.47 km) |
| Buffalo to Santa Barbara (California) | 2,257.48 mi (3,633.06 km) |
| Buffalo to Santa Clara (California) | 2,284.22 mi (3,676.10 km) |
| Buffalo to Santa Clara (Oregon) | 2,193.74 mi (3,530.48 km) |
| Buffalo to Santa Clarita (California) | 2,195.91 mi (3,533.98 km) |
| Buffalo to Santa Cruz (California) | 2,298.28 mi (3,698.72 km) |
| Buffalo to Santa Fe (New Mexico) | 1,526.95 mi (2,457.39 km) |
| Buffalo to Santa Fe (Texas) | 1,296.93 mi (2,087.20 km) |
| Buffalo to Santa Fe Springs (California) | 2,189.59 mi (3,523.81 km) |
| Buffalo to Santa Maria (California) | 2,278.21 mi (3,666.43 km) |
| Buffalo to Santa Monica (California) | 2,207.80 mi (3,553.11 km) |
| Buffalo to Santa Paula (California) | 2,226.71 mi (3,583.55 km) |
