| Buffalo to Oswego (Illinois) | 491.93 mi (791.68 km) |
| Buffalo to Oswego (New York) | 124.26 mi (199.98 km) |
| Buffalo to Otsego (Minnesota) | 749.94 mi (1,206.92 km) |
| Buffalo to Ottawa (Illinois) | 521.97 mi (840.03 km) |
| Buffalo to Ottawa (Kansas) | 907.35 mi (1,460.24 km) |
| Buffalo to Ottumwa (Iowa) | 708.40 mi (1,140.06 km) |
| Buffalo to Overland (Missouri) | 668.16 mi (1,075.30 km) |
| Buffalo to Overland Park (Kansas) | 870.89 mi (1,401.56 km) |
| Buffalo to Overlea (Maryland) | 272.85 mi (439.10 km) |
| Buffalo to Oviedo (Florida) | 992.73 mi (1,597.64 km) |
| Buffalo to Owasso (Oklahoma) | 1,010.51 mi (1,626.26 km) |
| Buffalo to Owatonna (Minnesota) | 724.60 mi (1,166.13 km) |
| Buffalo to Owensboro (Kentucky) | 561.67 mi (903.92 km) |
| Buffalo to Owings Mills (Maryland) | 263.82 mi (424.57 km) |
| Buffalo to Owosso (Michigan) | 269.45 mi (433.65 km) |
